张从刚
电子邮件：cgzhang@mail.tsinghua.edu.cn
研究方向：
本课题组长期从事天然免疫和线粒体质量调控等方向的基础研究，聚焦在DNA天然免疫信号通路、PINK1-Parkin信号通路、自身免疫性疾病、细菌与炎症等领域。实验室综合运用细胞生物学、结构生物学、生物化学和免疫学方法研究天然免疫、线粒体调控领域的核心机理和潜在应用。现阶段的研究工作主要集中于1.线粒体的质量调控与天然免疫的调控机制；2.细菌的环状核苷酸代谢通路与免疫的调控机理；3.上述机制、过程在炎症、自身免疫性疾病和神经退行性疾病治疗中的可能应用。
代表性科研论文：
1. Zhang C ?, Shang G ?, Gui X, Bai X, Zhang X, Chen J. Z. (2019). Structural Basis of STING Binding with and Phosphorylation by TBK1. Nature. 567: 394-398
2. Zhang C, Wang R, Liu Z, Bunker E, Lee S, Giuntini M, Chapnick D, and Liu X. (2019). The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1’s association with the mitochondrial protein TOM20. J Biol Chem. 294: 7472-7487
3. Shang G ?, Zhang C ?, Chen J. Z, Bai X, Zhang X. (2019). Cryo-EM Structures of STING Reveal Its Mechanism of Activation by Cyclic GMP-AMP. Nature. 567: 389-393
4. Zhang C ?, Liu Z ?, Bunker E ?, Ramirez A, Lee S, Peng Y, Tan AC, Eckhardt SG, Chapnick DA, Liu X. (2017). Sorafenib Targets the Mitochondrial Electron Transport Chain Complexes and ATP Synthase to Activate the PINK1-Parkin Pathway and Modulate Cellular Drug Response. J Biol Chem. 292: 15105-15120
5. Zhang, C., Lee, S., Peng, Y., Bunker, E., Shen, C., Giaime, E., Shen, J., Shen, J., Zhou, Z., and Liu, X. (2015). A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell research. 25(3):394-7.
6. Zhang, C., S. Lee, Y. Peng, E. Bunker, E. Giaime, J. Shen, Z. Zhou, and X. Liu. (2014). PINK1 Triggers Autocatalytic Activation of Parkin to Specify Cell Fate Decisions. Curr Biol. 24:1854-65.
7. Lee, S ?., Zhang, C ?., and Liu, X. (2014). Role of Glucose Metabolism and ATP in Maintaining PINK1 Levels During Parkin-mediated Mitochondrial Damage Responses. J Biol Chem. 290(2):904-17.